CNS demyelinating autoimmune diseases

CNS demyelinating autoimmune diseases
Central Nervous System.png
The demyelination of the Central Nervous System
SpecialtyNeurology, immunology Edit this on Wikidata

CNS demyelinating autoimmune diseases are autoimmune diseases which primarily affect the central nervous system.[1]


Examples include:


Since the neural impulse is inhibited in this condition it may lead to paresthesia, muscle weakness, unsteady gait, paralysis, vision loss and other motor dysfunctions.


CNS demyelination autoimmune disease causes the myelin sheath to deteriorate since the sense of recognition of self is lost. The loss of the myelin insulation either disrupts or prevents neural conduction along the nerve cell's axon.

Nervous System

The brain and the spinal cord are the essential components of the central nervous system and it is responsible for the integration of the signals received from the afferent nerves and initiates action. The nerve cells, known as neurons, carry impulses throughout the body and the nerve impulses are carried along the axon. These microscopic nerve fibers, where the action potential occurs, are protected by a white, fatty tissue that surrounds and insulates it, known as the myelin sheath. This insulation helps the axon of a nerve cell with the conduction and speed of the signal along the axon.


The pathogenesis of the demyelination can vary. Some of the factors that contribute to the deteriorating of the myelin are due to inflammatory processes, acquired metabolic derangements, viral demyelination, and hypoxic-ischaemic demyelination.


See also


  1. ^ "Demyelinating Autoimmune Diseases, CNS - MeSH - NCBI". Cite journal requires |journal= (help)

External links


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Brain and spinal cord; a manual for the study of the morphology and fibre-tracts of the central nervous system (1912) (14784117803).jpg
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Identifier: cu31924003167578 (find matches)
Title: Brain and spinal cord; a manual for the study of the morphology and fibre-tracts of the central nervous system
Year: 1912 (1910s)
Authors: Villiger, Emil, 1870-1931 Piersol, George A. (George Arthur)
Subjects: Brain Spinal cord
Publisher: Philadelphia, London, J. B. Lippincott
Contributing Library: Cornell University Library
Digitizing Sponsor: MSN

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Fig. 49.—Frontal section of the brain, mrijmgh the septum pellueidum, which extends between the body (Corp, callos.)and the: rostrum (C. c.) of the corpus ealloluii/ and forms the medial wall of the anterior horns of the lateral ventricles.The corpus striatum is partially divided byithe capsula interna. CI, claustrum,
Text Appearing After Image:
Pig. 50.—Frontal section of the brain, through the tips of the temporal lobes. Cc, corpus callosum, lamina rostralis;Co, oommissura anterior; C. ext., capsula externa; CI, claustrum; C. exlr., capsula extrema. 48 MORPHOLOGY. The nucleus lentiformis, or nucleus lenticularis, constitutes a wedge-shaped mass,whose base is directed outward and the apex inward. It lies lateral and, at the sametime, ventral to the nucleus caudatus and thalamus, Separated from the latter by theinternal capsule. In front and ventrally, the lenticular nucleus is directly continuouswith the head of the nucleus caudatus. Dorsally, delicate gray stripes connect the twonuclei; hence the designation corpus striatum applied to the nuclei conjointly. Thenucleus lentiformis bounds the internal capsule laterally with its downward and inwardsloping medial surface. Its shghtly convex lateral surface is vertical and borders thecapsula externa, a thin white medullary lamella which is limited externally by a

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The demyelination of the Central Nervous System.