Poliovirus binding receptor 1DGI.png
Available structures
PDBHuman UniProt search: PDBe RCSB
AliasesPVR, CD155, HVED, NECL5, Necl-5, PVS, TAGE4, poliovirus receptor, PVR cell adhesion molecule
External IDsOMIM: 173850 HomoloGene: 9672 GeneCards: PVR
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 19: 44.64 – 44.67 Mbn/a
PubMed search[2]n/a
View/Edit Human

CD155 (cluster of differentiation 155) also known as the poliovirus receptor is a protein that in humans is encoded by the PVR gene.[3][4]


CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily.[5] Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells.[6] The role of CD155 in the immune system is unclear, though it may be involved in intestinal humoral immune responses.[6] Subsequent data has also suggested that CD155 may also be used to positively select MHC-independent T cells in the thymus.

The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication.[3]


CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus.[7]

Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy[8] while a high resolution structures of the ectodomain D1 and D2 of CD155 were solved by x-ray crystallography.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000073008 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: poliovirus receptor".
  4. ^ Koike S, Horie H, Ise I, Okitsu A, Yoshida M, Iizuka N, Takeuchi K, Takegami T, Nomoto A (October 1990). "The poliovirus receptor protein is produced both as membrane-bound and secreted forms". EMBO J. 9 (10): 3217–24. doi:10.1002/j.1460-2075.1990.tb07520.x. PMC 552052. PMID 2170108.
  5. ^ Mendelsohn CL, Wimmer E, Racaniello VR (1989). "Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily". Cell. 56 (5): 855–65. doi:10.1016/0092-8674(89)90690-9. PMID 2538245. S2CID 44296539.
  6. ^ a b Maier MK, Seth S, Czeloth N, et al. (2007). "The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens". European Journal of Immunology. 37 (8): 2214–25. doi:10.1002/eji.200737072. PMID 17621371. S2CID 24583092.
  7. ^ a b PDB: 3epc​, 3epd​, 3epf​, 3eow​;Zhang P, Mueller S, Morais MC, Bator CM, Bowman VD, Hafenstein S, Wimmer E, Rossmann MG (November 2008). "Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses". Proc. Natl. Acad. Sci. U.S.A. 105 (47): 18284–9. Bibcode:2008PNAS..10518284Z. doi:10.1073/pnas.0807848105. PMC 2587566. PMID 19011098.
  8. ^ PDB: 1DGI​;He Y, Bowman VD, Mueller S, Bator CM, Bella J, Peng X, Baker TS, Wimmer E, Kuhn RJ, Rossmann MG (January 2000). "Interaction of the poliovirus receptor with poliovirus". Proc. Natl. Acad. Sci. U.S.A. 97 (1): 79–84. doi:10.1073/pnas.97.1.79. PMC 26619. PMID 10618374.

External links

  • Human PVR genome location and PVR gene details page in the UCSC Genome Browser.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Media files used on this page

HSR 1996 II 3.5e.svg
Author/Creator: Health and Safety Executive, Licence: OGL v1.0
Illustration from Safety signs and signals: Safety signs and signals. The Health and Safety (Safety Signs and Signals) Regulations 1996
Human chromosome 19 ideogram.svg
Human chromosome 19. G-banding ideogram in resolution 850 bphs.
Red rectangle 2x18.png
Author/Creator: me, Licence: CC0
Vertical red rectangle. 2px wide by 18px high.
Ideogram human chromosome 19.svg
Ideogram of human chromosome. Chromosome 19 highlighted. G-band, 850 bphs (bands per haploid set). Black and gray: Giemsa positive. Red: Centromere. Light blue: Variable region. Dark blue: Stalk.
Poliovirus binding receptor 1DGI.png
Schematic model of poliovirus, serotype 1 (Mahoney) binding CD155 (extracellular domain shown in purple).
Created using QuteMol ( and GIMP. Style made to resemble the Protein Data Bank's "Molecule of the Month" series, illustrated by Dr. David S. Goodsell of the Scripps Research Institute.
DNA stub.png
Author/Creator: The original uploader was Alai at English Wikipedia., Licence: CC-BY-SA-3.0
Cropped and rotated version of en:Image:DNA_Overview.png, for use in stub templates.