Andrea Crisanti (scientist)

Andrea Crisanti
Born (1954-09-14) September 14, 1954
NationalityItalian
Alma mater
Scientific career
Institutions
Doctoral studentsFlaminia Catteruccia
Websitewww.imperial.ac.uk/people/a.drcrisanti

Andrea Crisanti (born 1954) is an Italian full professor of Microbiology at the University of Padua. He previously was professor of Molecular Parasitology at Imperial College London. He is best known for the development of genetically manipulated mosquitoes with the objective to interfere with either their reproductive rate or the capability to transmit diseases such as malaria.[1]

Biography

Crisanti earned his Master of Medicine and Surgery degree in Italy at Sapienza University of Rome.[2] At the Basel Institute for Immunology, while studying for his PhD, Crisanti discovered the IL2 receptor of immature thymocytes. Crisanti served as a Postdoctoral Fellow at the Center for Molecular Biology (ZMBH) at the University of Heidelberg. In 1994, Crisanti became a lecturer at Imperial College, before being appointed Professor in 2000. He is also the director of the Centre of Functional Genomics at the University of Perugia.[3] He is an author of over 100 scientific publications in leading scientific journals, including Proceedings of the National Academy of Sciences of the United States of America, The EMBO Journal, Cell, Science and Nature.

At Imperial College London, Crisanti has established the technologies to eliminate the human malaria vector Anopheles gambiae. Crisanti's work exploits the biological properties of a class of selfish genetic elements (homing endonuclease) to develop a gene transfer technology. Using such technology, Crisanti has developed genetically manipulated mosquitoes producing a male-only progeny. In the future, further refinements of the technology may lead to the development of vector control tools based on the release of just a few genetically modified mosquitoes. Via natural breeding, the genes can effectively spread to large field mosquito populations, reducing malaria-spreading mosquito numbers in the wild and ultimately decreasing malaria incidence.[4][5] In 2018, Crisanti and colleagues demonstrated that CRISPR/Cas9 can be programmed to attack a conserved region of the sex determination gene, doublesex, which impairs female mosquito development and could spread effectively to 100% of a population in a few generations.[6] This study represents the first time that researchers have been able to block the reproductive capacity of a complex organism in the laboratory using designer molecular approaches.[7]

In 2011, Crisanti was appointed editor-in-chief of medical journal Annals of Tropical Medicine and Parasitology, which in 2012 under Crisanti's leadership became Pathogens and Global Health, reflecting the journal's newly formed broader focus.[8] Crisanti is a chairman of the scientific panel of the EU Marie Curie Programme, I-Move, and has advised on issues concerning the safety of genetically modified insects for the Consilium Pontificium of the Vatican City[9] and the European Food Safety Authority.[10]

COVID-19

In March 2020 during the COVID-19 pandemic in Italy, Crisanti conducted analysis of citizens in and found that most of the infected people were asymptomatic carriers; without symptoms but capable of spreading the COVID-19 virus.[11][12] Crisanti's research, which was published in Nature,[13] was strongly supported by a BMJ editorial which appeared on 1 July.[14] Crisanti is highly critical of the World Health Organization. His throat swab test methodology was complete on 25 January (the date is an error) and amongst the first in the world. Crisanti demanded and obtained the co-operation of the President of Veneto, Luca Zaia, in the teeth of opposition by the WHO, which had co-opted the administration of Giuseppe Conte. In neighbouring Lombardy the death toll exceeded 16,800 while in Veneto it was minimal. In the opinion of Crisanti,

the WHO guidelines were completely wrong, an incredible example of incoherence... Their bureaucrats were far away from the problem and far away from the science. I think what Donald Trump did [moving to pull United States out of WHO] is one of the few things he's done that I can agree with.

References

  1. ^ "Projects". Crisanti Lab. Retrieved 24 February 2015.
  2. ^ http://phdsgb.unipv.eu/site/home/docenti/documento630010945.html
  3. ^ "Andrea Crisanti - CV" (PDF). University of Perugia. Retrieved 24 February 2015.
  4. ^ Webb, Jonathan (10 June 2014). "GM lab mosquitoes may aid malaria fight". BBC News. Retrieved 24 February 2015.
  5. ^ Galizi, Roberto; Doyle, Lindsay; Menichelli, Miriam; Bernardini, Federica; Deredac, Anne; Burt, Austin; Stoddard, Barry; Windbichler, Nikolai; Crisanti, Andrea (10 June 2014). "A synthetic sex ratio distortion system for the control of the human malaria mosquito". Nature Communications. 5: 3977. Bibcode:2014NatCo...5.3977G. doi:10.1038/ncomms4977. PMC 4057611. PMID 24915045.
  6. ^ Crisanti, Andrea; Nolan, Tony; Beaghton, Andrea K.; Burt, Austin; Kranjc, Nace; Galizi, Roberto; Hammond, Andrew M.; Kyrou, Kyros (24 September 2018). "A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes". Nature Biotechnology. 36 (11): 1062–1066. doi:10.1038/nbt.4245. ISSN 1546-1696. PMC 6871539. PMID 30247490.
  7. ^ Dunning, Hayley (24 September 2018). "Mosquitoes that can carry malaria eliminated in lab experiments | Imperial News | Imperial College London". Imperial News. Retrieved 2019-03-21.
  8. ^ "An interview with Andrea Crisanti, Editor of Pathogens and Global health". YouTube Maney Publishing Channel. Retrieved 24 February 2015.
  9. ^ "Pontifical Council for Justice and Peace" (PDF). The Vatican Publications. Retrieved 10 March 2015.
  10. ^ "Panel on Genetically Modified Organisms" (PDF). European Food Safety Authority. Archived from the original (PDF) on 12 November 2011. Retrieved 10 March 2015.
  11. ^ Crisanti, Andrea; Cassone, Antonio (20 March 2020). "In one Italian town, we showed mass testing could eradicate the coronavirus". The Guardian / University of Padua. Archived from the original on 23 March 2020. asymptomatic or quasi-symptomatic subjects represent a good 70% of all virus-infected people and, still worse, an unknown, yet impossible to ignore portion of them can transmit the virus to others
  12. ^ Reguly, Eric (24 July 2020). "The Italian scientist who challenged the WHO guidelines and spared a town from the pandemic". The Globe and Mail Inc.
  13. ^ Lavezzo, E.; Franchin, E.; Ciavarella, C.; Cuomo-Dannenburg, G.; Barzon, L.; Del Vecchio, C.; Rossi, L.; Manganelli, R.; Loregian, A.; Navarin, N.; Abate, D.; Sciro, M.; Merigliano, S.; De Canale, E.; Vanuzzo, M. C.; Besutti, V.; Saluzzo, F.; Onelia, F.; Pacenti, M.; Parisi, S. G.; Carretta, G.; Donato, D.; Flor, L.; Cocchio, S.; Masi, G.; Sperduti, A.; Cattarino, L.; Salvador, R.; Nicoletti, M.; et al. (2020). "Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo'". Nature. 584 (7821): 425–429. Bibcode:2020Natur.584..425L. doi:10.1038/s41586-020-2488-1. PMID 32604404. S2CID 220286952.
  14. ^ Mahase, Elisabeth (2020). "Covid-19: Four in 10 cases in Italian town that locked down early were asymptomatic". BMJ. 370: m2647. doi:10.1136/bmj.m2647. PMID 32611551.

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